Vipera berus berus Venom from Russia: Venomics, Bioactivities and Preclinical Assessment of Microgen Antivenom
نویسندگان
چکیده
منابع مشابه
Proteome and Peptidome of Vipera berus berus Venom.
Snake venom is a rich source of peptides and proteins with a wide range of actions. Many of the venom components are currently being tested for their usefulness in the treatment of many diseases ranging from neurological and cardiovascular to cancer. It is also important to constantly search for new proteins and peptides with properties not yet described. The venom of Vipera berus berus has hem...
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Secretory phospholipasesA(2) (sPLA(2)s) form a large family of structurally related enzymes widespread in nature. Herein, we studied the inhibitory effects of sPLA(2)s from Vipera lebetina (VLPLA(2)), Vipera berus berus (VBBPLA(2)), and Naja naja oxiana (NNOPLA(2)) venoms on (i) human platelets, (ii) four different bacterial strains (gram-negative Escherichia coli and Vibrio fischeri; gram-pos...
متن کاملImmunological Cross-Reactivity and Neutralisation of European Viper Venoms with the Monospecific Vipera berus Antivenom ViperaTAb
Medically important cases of snakebite in Europe are predominately caused by European vipers of the genus Vipera. The mainstay of snakebite therapy is polyclonal antibody therapy, referred to as antivenom. Here we investigate the capability of the monospecific V. berus antivenom, ViperaTAb®, to cross-react with, and neutralise lethality induced by, a variety of European vipers. Using ELISA and ...
متن کاملSecond-degree heart block associated with envenomation by Vipera berus.
Evenomation by the common European adder (Vipera berus) is well known for its significant morbidity but low mortality. Cardiac complications tend to take second place to the systemic upset and usually only comprise non-specific ECG changes. This case illustrates many of the classical features of adder bite but it is also the first account of heart block as a complication.
متن کاملHospital contacts after bite by the European adder (Vipera berus).
INTRODUCTION Bites by the European adder, Vipera berus, may cause significant morbidity in bite victims, but this can be reduced through adequate treatment. Since the previous Danish study, a new treatment and a severity grading has been taken into use. The aims of this study were to review clinical cases after a bite from V. berus in The North Denmark Region and to evaluate the treatment given...
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ژورنال
عنوان ژورنال: Toxins
سال: 2019
ISSN: 2072-6651
DOI: 10.3390/toxins11020090